I've changed my tune a bit on this:
People outright changing their settings (like everything low and using configs to get extra visibility etc) I have a problem with that, people would do this in Source Engine Games and it's basically hacking in my view (making objects transparent through configs and forcing lower direct X versions).
But I have to admit to doing a bit of setting changing myself in Rising storm 2 (i.e turning off Anti-Aliasing actually makes the Game playable because you can actually see enemies) otherwise it's like having vaseline smeared over your screen.